BOIN Design Calculator & Decision Table

Bayesian Optimal Interval (BOIN) design for phase I clinical trials

Design Parameters

Number of Doses:

Starting Dose Level:

Cohort Size:

Number of Cohorts:

Maximum number of patients per dose (m):

Target Toxicity & Boundaries

Target Toxicity Probability (φ):

Lower Toxicity Bound (φ₁): Default = 0.6×φ

Upper Toxicity Bound (φ₂): Default = 1.4×φ

Modify decision from de-escalation to stay when observing 1 DLT out of 3 patients

Modify decision from stay to de-escalation when observing 2 DLTs out of 6 patients

Perform accelerated titration

Dose Decision Calculation

Number of Patients at Current Dose (n):

Number of Observed DLTs (x):

Decision Result

Decision Table

Generate a decision table with columns representing the number of evaluable subjects (from the cohort size to m) and rows indicating:

Decision Table